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Image Search Results


Graphical illustration of study design TCIA, The Cancer Imaging Archive; TCIA-LGG, The Cancer Genome Atlas Low Grade Glioma; UCSF-PDGM, The University of California San Francisco Preoperative Diffuse Glioma MRI; TCGA-GBM, The Cancer Genome Atlas Glioblastoma Multiforme Collection; CPTAC-GBM, The Clinical Proteomic Tumor Analysis Consortium Glioblastoma Multiforme Collection; IvyGAP, Ivy Glioblastoma Atlas Project; ROI, region of interest; THPA, The Human Protein Atlas.

Journal: Cell Reports Medicine

Article Title: Predicting glioma survival and extracellular matrix remodeling through MRI radiogenomics

doi: 10.1016/j.xcrm.2026.102775

Figure Lengend Snippet: Graphical illustration of study design TCIA, The Cancer Imaging Archive; TCIA-LGG, The Cancer Genome Atlas Low Grade Glioma; UCSF-PDGM, The University of California San Francisco Preoperative Diffuse Glioma MRI; TCGA-GBM, The Cancer Genome Atlas Glioblastoma Multiforme Collection; CPTAC-GBM, The Clinical Proteomic Tumor Analysis Consortium Glioblastoma Multiforme Collection; IvyGAP, Ivy Glioblastoma Atlas Project; ROI, region of interest; THPA, The Human Protein Atlas.

Article Snippet: Database: The Human Protein Atlas version 24.0 , Global Core Biodata Resource , https://www.proteinatlas.org/.

Techniques: Imaging

The protein expression patterns of radiogenomics-based hub genes (A) The protein expression patterns of 7 hub genes between normal brain tissues and glioma were determined by immunohistochemistry (IHC) staining from The Human Protein Atlas (THPA) database. Compared with normal brain tissues, the protein expression levels of hub genes increased in glioma as the grading of the tumor increased, except for CXCL8 and IL-6 without obvious detection. (B) IHC staining of acquired glioma specimens in proliferative core exhibited higher protein expression levels of MMP2, MMP9, TIMP1, COL1A2, and CCL2 in the high-Rad-score group. Compared with the hub gene labeling index (LI) in the low-Rad-score group, LIs of MMP2, TIMP1, and COL1A2 were significantly higher in the high-Rad-score group (∗ p < 0.05; ∗∗ p < 0.01; ∗∗∗ p < 0.001). (C) The expression levels and localization of MMP2, TIMP1, and COL1A2 were shown by the multiplex immunohistochemistry (mIHC) staining. The biological markers represented by different colors are labeled in the figure. The expression of the three genes increased in the high-Rad-score group, and MMP2 exhibited the most significant difference.

Journal: Cell Reports Medicine

Article Title: Predicting glioma survival and extracellular matrix remodeling through MRI radiogenomics

doi: 10.1016/j.xcrm.2026.102775

Figure Lengend Snippet: The protein expression patterns of radiogenomics-based hub genes (A) The protein expression patterns of 7 hub genes between normal brain tissues and glioma were determined by immunohistochemistry (IHC) staining from The Human Protein Atlas (THPA) database. Compared with normal brain tissues, the protein expression levels of hub genes increased in glioma as the grading of the tumor increased, except for CXCL8 and IL-6 without obvious detection. (B) IHC staining of acquired glioma specimens in proliferative core exhibited higher protein expression levels of MMP2, MMP9, TIMP1, COL1A2, and CCL2 in the high-Rad-score group. Compared with the hub gene labeling index (LI) in the low-Rad-score group, LIs of MMP2, TIMP1, and COL1A2 were significantly higher in the high-Rad-score group (∗ p < 0.05; ∗∗ p < 0.01; ∗∗∗ p < 0.001). (C) The expression levels and localization of MMP2, TIMP1, and COL1A2 were shown by the multiplex immunohistochemistry (mIHC) staining. The biological markers represented by different colors are labeled in the figure. The expression of the three genes increased in the high-Rad-score group, and MMP2 exhibited the most significant difference.

Article Snippet: Database: The Human Protein Atlas version 24.0 , Global Core Biodata Resource , https://www.proteinatlas.org/.

Techniques: Expressing, Immunohistochemistry, Labeling, Multiplex Assay, Staining